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KMID : 1137820110320020085
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의공학회지
2011 Volume.32 No. 2 p.85 ~ p.92
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Development of Correction Technologies for Quantification of Photon Measurement in Bio-Luminescence Image
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Tak Yoon-Oh
Kim Hyeon-Sik
Park Hyeong-Ju
Choi Heung-Kook
Choi Eun-Seo
Hann Swook
Lee Byeong-Il
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Abstract
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Bioluminescence imaging (BLI) is the most sensitive animal imaging technique for molecular imaging research. Generally, highly sensitive CCD is used to detect an optical probe introduced in a living mouse. However, in many cases, the light signal emitted from a probe is too small to detect because it is scattered and attenuated by the tissue prior to being detected. The problem is that scattering and attenuation not only inhibit accurate measurement but also make image quality down. Thus we introduced a new method to reduce noise by using property of CCD and method to improve image quality of bioluminescence image by using two steps Gaussian blurring.
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KEYWORD
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bioluminescence image, CCD noise correction, Gaussian blur, photon quantification
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